MRI & Ultrasound Results

 

 

 

Since our last appointment with the genetics doctor in Syracuse Dr. Pellegrino, we have had 3 of the 9 needed testing done. On February 23rd, Hunter and Kingston both had MRI's with general anesthesia and Kingston had an ultrasound.
The MRI's evaluated for hydrocephalus and other brain abnormalities that are associated with the disease. They both showed no signs of fluid sitting on the brain, whic...h we are very relieved since they have both always had big heads. They both have numerous dilated perivascular spaces due to Hunters Syndrome. 

 They both have a buildup of white matter on their frontal lobe and on the left and right sides behind their ears. Our doctor described this as cement build up. Once it is there, there is no way to get rid of it.

 

It showed that they have severe bilateral maxillary sinusitis, severe left otomastoiditis and moderately severe right otomastoiditis. Dr. Pellegrino wanted them on an anti-biotic right away. Their pediatrician believes that it is just a build up from this disease and that an antibiotic would not help and that the test results would be the same if they had another MRI a month from now. He prescribed us the anti-biotic any ways. Better safe than sorry. He said if they had such a severe infection that they would have fevers and it would be tender behind their ears and a deformity of the ear would be noticeable. He believes it’s the “cement” buildup from the mucopolysaccharides.
There also are signs of thickening in the blood vessels and other parts of the brain due to the disease.
Kingston has white matter myelination that is mildly and subjectively delayed in bilateral temporal, subinsular and peritrigonal regions. White matter volume is normal with normal myelination elsewhere.

 Hunter has subjective mild delay of white matter myelination in bilateral parieto-occipital, subinsular and possibly in juxtacortical regions.
On a GOOD note, the doctor said that their development from MPS 2 is not harming their brain development at this point in time. :-)

Kingston’s Ultrasound results came back that his left liver is enlarged, but no signs of hepatosplenomegaly, which is the simultaneous enlargement of both the liver (hepatomegaly) and the spleen (splenomegaly).

 Hunter had an ultrasound back in November and that showed that he did have hepatosplenomegaly. He has a mildly enlarged liver and spleen.